Fig. 3

Protective effects of rebamipide on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor deficits in mice. Rebamipide was administered for 5 d. Representative images of mouse movement in the open field box, as captured by the video tracking system. The total distance covered by the mice was quantified in the open field box 7 d after MPTP injection (A and E). Latency time on the rotarod was recorded 7 d after MPTP injection, with a 300 s cutoff limit (B). The time it took to turn completely downward (C) and the time to fall off the rod onto the floor (D) were recorded 7 d after MPTP injection, with a 60 s cutoff limit. Data are presented as mean ± standard error of mean (SEM). * p < 0.05, ** p < 0.01, ***p < 0.001, compared with the control group; # p < 0.05, ## p < 0.01, ###p < 0.001, compared with the MPTP-treated group