Fig. 7

Schematic representation of the proposed TRIM7-MCT4 axis in astrocyte reactivity during EAE. During MS and EAE, downregulated expression of E3 ubiquitin ligase TRIM7 reduced the ubiquitin-proteasome pathway dependent degradation of MCT4. Increased MCT4 interacted with NF-κB and c-Myc, promoting the phosphorylation and nuclear translocation of NF-κB and c-Myc. The activation of the aforementioned pathways further facilitated the activation of astrocytes via promoting astrocytic glycolysis and proliferation during EAE