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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats

Fig. 6

Active-phase fasting altered the levels of rhythmic genes in the ileum and colon of dams. a Relative mRNA expression levels of rhythmic genes in the ileum, including clock, Bmal1, per1, per2, cry1, cry2, Rev-Erbα, Rorα, nampt, and DBP (ND group: n = 8; IF group: n = 7). b Relative mRNA expression levels of rhythmic genes in the colon, including clock, Bmal1, per1, per2, cry1, cry2, Rev-Erbα, Rorα, nampt, and DBP (ND group: n = 8; IF group: n = 7). The results in panels a and b were presented as mean ± SEM. c Heatmap showing correlations between rhythmic genes and intestinal inflammatory factors in the ileum and colon, where yellow indicated a positive correlation, and purple indicated a negative correlation. "ns" indicated no statistical significance (p > 0.05), and superscript asterisks denoted statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094