Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats

Fig. 4

Active-phase Fasting Altered Cecal Microbiota Composition in Pregnant Rats and Increased the LPS Biosynthesis Pathway. a Taxonomic composition of the cecal microbiota at the phylum level. b Heatmap of relative expression levels of differentially abundant genera, with data normalized for comparison. c Microbial taxa unique to the active-phase fasting group were identified using LEfSe analysis. d Functional predictions of bacterial communities based on PICRUSt2. e Circular Spearman correlation heatmap showing the relationships between differentially abundant species and levels of serum/hippocampal inflammatory cytokines and antioxidant capacities. f Correlation between differentially abundant genera and markers of ileal/colonic integrity and inflammatory factors, depicted using Spearman correlation. In heatmaps e–f, yellow indicated positive correlations, and purple indicated negative correlations. Results in panel d were presented as mean ± SEM. Statistical significance was denoted as follows: ns indicated no statistical difference (p > 0.05); *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094