Fig. 9

Validation of proteins and metabolites associated with ferroptosis and identified by random forest by independent cohorts. (A). Schematic for an independent cohort. (B) Validation of ferroptosis-related proteins and metabolites. (C) Validation of Biomarkers Identified by Machine Learning. It is noteworthy that uracil is not only the most significant biomarker for differences and RF top, but also an ferroptosis-related metabolite. (D) ROC analysis of validated biomarkers