Fig. 1
Activation of BrafV600E mutation drives BAVMs in mice, accompanied by an inflammatory and hypoxic microenvironment. A A diagram illustrating the model establishment. B Images of fresh brain tissues of control and BAVM group. Images of (i′)–(iv′) were locally magnified images. Yellow arrows indicate hemorrhagic spots. Black scale bar = 2 mm, white scale bar = 500 μm. C–F The quantification of the number of surface hemorrhage (n = 6 mice). G Representative images of latex-casted clarified brains at 4 th week after AAV injection. Images of (i′)–(ii′) were locally magnified images. Yellow arrows indicate the lesions and red arrows indicate hemorrhagic spots. Black scale bar = 2 mm and white Scale bar = 500 μm. H Images of H&E staining of brain sections. Scale bar = 100 μm. I Representative images of Evans Blue Dye perfusion in control and BAVM mice. Scale bar = 20 μm