Fig. 2
From: Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia
Vascular cellular heterogeneity after moderate TBI. (A) UMAP of vascular cells combined from sham and TBI normothermic animals (n = 3 biological replicates per group). Cells are colored by vascular subtype. (B) Same UMAP arranged by injury condition, sham (red) and TBI (yellow), shows TBI-specific cell types. (C) Proportion of each vascular cell type before and after TBI shows cell type-specific effects of TBI on endothelial cell subtypes (left) and perivascular cell subtypes (right). Each data point is a biological replicate. Error bar = SEM (D) Dot plot of unique marker genes used to identify each major cell type. (E) GO biological processes based on the top DEG of each subpopulation compared to all others and plotted on a log scale of its p-value (p < 0.001). The size of the circle represents the number of genes that defines the GO term, and the color of the circle represents its odds ratio