Fig. 1
From: Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia
Cellular composition of the cortical injury site after moderate TBI. (A) UMAP of cells from normothermic sham and TBI cortex at 24 h post-injury shows all major cell types (n = 3 biological replicates per group). Cells are colored by cell-type. (B) Same UMAP arranged by injury condition, sham (red) and TBI (yellow), shows TBI-specific cell types. (C) Proportion of each cell type before and after TBI shows cell type-specific effects of TBI, and that microglia, endothelial cells, and astrocytes comprise majority of the cell types in the dataset. Each data point is a biological replicate. Error bar = SEM (D) Dot plot of unique marker genes used to identify each major cell type