Fig. 3

EED inhibitors mediate the transcriptional programs for DC migration. A PCA of the transcriptome profiles of DC2.4 after treating with EEDi-5285 (5 μM) for 24 h and LPS (50 ng/mL) for 6 h. n = 3 independent experiments. B Volcano plot of the transcriptome profiles from vehicle and EEDi-5285 group (fold-change > 2, P < 0.05). C Heatmap analyses of the differentially expressed genes vehicle and EEDi-5285 group. D GSEA analyses of genes enriched in vehicle or EEDi-5285 group. E The relative counts of indicated genes in DC2.4 from vehicle and EEDi-5285 group. F–H GSEA enrichment scores for indicated gene sets in vehicle or EEDi-5285 group. I The relative counts of indicated genes in DC2.4 from vehicle and EEDi-5285 group. Data are presented as mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001