Fig. 1

Optical coherence tomography (OCT) imaging of the optic nerve: A) Illustration of the posterior pole of the human retina, showing the area of typical clinical OCT images of the optic nerve head and macula (black boxes). B) High-definition raster image of a single OCT b-scan showing details of the retinal layers, highlighting the retinal ganglion cell (RGC) layer, where the ganglion cell bodies reside, as well as the retinal nerve fiber layer, where the RGC axons course toward the optic nerve head. The thickness of each of these layers is shown en face in panel C. C) The black boxes recapitulate the retinal area shown in panel B. Clinical reports use normative data to highlight areas of excessive thickening in cases of swelling, or thinning in cases of atrophy