Fig. 4

TREM2 expression does not alter microglia density

(A-C) Representative images of piriform cortical region (A) and quantification (B and C) of microgliosis by immunofluorescence staining with Iba1 antibody. Scale bar, 500 μm. (D-F) Representative images of hippocampus (D) and quantification (E and F) of microgliosis by Iba1 immunofluorescence staining. Scale bar, 500 μm. Sample size: n = 19–23 mice/group, with mixed sexes. Each datapoint (circle) represents an individual animal, male and female mice are labeled as solid and open circles, respectively. Data are shown as mean ± SEM. Mann-Whitney tests were used for statistical analysis. P values < 0.05 were considered to be statistically significant. N.S., not significant.