Fig. 3

Moss-derived recombinant human CFH variants reduce formation of membrane attack complex and mononuclear phagocyte migration in light-exposed retinas. A Representative images from Iba1-, C5b-9 membrane attack complex (MAC)—and DAPI-stained cryosections from control and light-exposed mice at indicated time points. AF, autofluorescence. Scale bar: 100 µm. ONL, outer nuclear layer; INL, inner nuclear layer and GCL, ganglion cell layer. B, C Quantification of Iba1⁺ cells in ONL (B) and in SRS (C) at indicated time points. D Quantification of C5b-9 area in SRS and ONL. Data show mean ± SEM; n = 9–13 retinas. One-way ANOVA followed by Sidak’s multiple comparison test; *P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001