Fig. 1

Moss-derived recombinant human CFH variants CPV-101 and CPV-104 reduce accumulation of Iba1⁺ cells in the subretinal space. A Representative images from Iba1-stained retinal flat mounts and autofluorescence (AF) in the subretinal space (SRS) one, three and four days after light exposure of mice treated with 5 µg CPV-101, CPV-104 or vehicle control. Scale bar: 100 µm. B Quantification of Iba1⁺ area in SRS. C Quantification of Iba1⁺ cells in SRS. D Quantification of autofluorescent area. Data shown as mean ± SEM, n = 9–11 retinas. One-way ANOVA followed by Sidak’s multiple comparison test; *P < 0.05, **P < 0.01 and ***P ≤ 0.001