Fig. 5

Treatment with anti-MCMV mAbs limits hearing loss in MCMV infected mice. (A) Auditory brainstem responses (ABR) clicks and (B) tones were performed on PNd34 in all mice. Significantly more ears in mice infected (MCMV) and isotype control antibody treated (MCMV + ISO) exhibited hearing loss compared to uninfected controls (MOCK) and/or infected mAb treated mice (MCMV + mAb). Noted that hearing loss was across the entire cochlea as indicated by the loss across frequencies from 4–48 kHz. Each datapoint represents an individual ear with median values shown. Statistical significance was determined by a Kruskal-Wallis test followed by a Dunn’s multiple comparisons post-test (^**P < 0.01, ^****P < 0.0001). For each experimental group, n = 7–26 mice (14–52 ears)