Fig. 4
Positive correlation between cochlear inflammatory response and the viral load. Cochlear expression of IFIT1, TNFα, and IFNγ in PNd4 MCMV infected mice was plotted as a function of cochlear viral load from the same animal to establish correlation between gene expression of inflammatory mediators and respective viral load. Red triangles (
) represent samples from mAb treated mice and open circles (
) represent samples from isotype control antibody treated or untreated but infected mice. Each data point represents an individual cochlea/matching cochlear viral load. Note that all viral load values, even those with values below the LD of the assay, were included in this analysis to limit bias from selection of only specimens with values above the LD of the assay. A Pearson’s correlation was performed to determine the r value with a 95% confidence interval for each gene. For correlation with IFIT1: r = 0.6147, P = 0.0005; TNFα: r = 0.6579, P = 0.0001; and IFNγ: r = 0.5249, P = 0.0041. Each correlation, n = 13 - 14 mice (26 -- 28 cochleae)