Fig. 1

Asrij depletion alleviates cognitive deficits and anxiety-like behavior in APP/PS1 mice. A Schematic showing behavioral tests used to assess cognitive performance of mice. B Graph shows quantification of latency to platform across 5 days of invisible platform training (acquisition) in Morris water maze (MWM) test (n = 13, all males) C Representative images of mouse tracks during MWM probe trial. The red circle indicates the location of the platform during training. Graphs show quantification of D latency, E cross number, F the percentage of time spent in the target quadrant, and G swimming speed (cm/s) during the MWM probe trial (n = 13, all males). H Representative traces of mouse path in open field test (OFT). The red box shows the center zone. Graphs show quantification of I entries in the center zone, J the percentage of distance traveled in the center zone, K the percentage of time spent in the center zone, L total distance traveled, and M mean speed (cm/s) in OFT (n = 8, all males). Statistical significance between experimental groups was calculated by repeated-measures two-way ANOVA with Bonferroni’s post hoc test (B) and one-way ANOVA with Bonferroni’s post hoc test (D–G and I–M). Error bars denote the mean ± SEM. ns: non-significant, *P < 0.05, **P < 0.01, and ***P < 0.001