Fig. 4
From: MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice
Transcriptome profiles of hippocampus microglia in 7-month-old Mr1−/− P301S mice and control Mr1+/+ P301S mice A UMAP plot showing different clusters of microglia/macrophage in the hippocampus of 7-month-old mice by single-nucleus RNA-seq analysis. Shown are all microglia/macrophage pooled from four 7-month-old Mr1−/− P301S mice and four control Mr1+/+ P301S mice. B Dot plots showing expressional levels of the indicated genes of each subset. C Percentages of each microglia and macrophage subset. D UMAP plots showing different clusters of microglia/macrophage in the hippocampus of 7-month-old Mr1−/− P301S mice and control Mr1+/+ P301S mice separately. E Enrichment of the indicated gene sets in M_inflammatory cells versus the other microglia/macrophage subsets. F Volcano plots depict genes that are significantly upregulated or downregulated in M_inflammatory cells compared to other microglia/macrophage cells. G Dot plots showing expressional levels of the indicated genes of each subset. Data are from 4 mice per group. Sex information in Additional file 1. Error bars = mean ± SEM. *p < 0.05. Sex information in Additional file 1