Fig. 4

ErbB4 small molecule agonist can improve mitochondrial damage in hippocampal neurons of mice exposed to PS-MPs. (A) The ultrastructural integrity of hippocampal neuronal mitochondria was evaluated using transmission electron microscopy (TEM). (B) Statistical analyses were performed on data pertaining to the hippocampal neuronal mitochondria. (C) The expression levels of mitochondria-associated proteins, including phosphorylated mTOR (p-mTOR), mTOR, and SIRT3, in the hippocampus of mice were quantified via western blot analysis. (D) Statistical analyses of these protein expression levels were conducted using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. The original magnification for mitochondrial imaging was 2000×, with a scale bar of 5 μm. Data are presented as means ± SEM. Statistical significance was indicated by *p < 0.05, **p < 0.01, and ***p < 0.001, with a sample size of n = 4 per group