Table 3 Cargos associated with angiogenesis and their roles in ischemic stroke

CXCR4

MCAO Mice

Brain tissue

Angiogenesis via SDF-1/CXCR4 pathway

[177]

MCAO Mice

Brain tissue

Angiogenesis

[179]

stroke patients

Serum

Stroke-induced mesenchymal stem cell migration

[180]

VEGF

MCAO rats

Brain tissue

Promotion of angiogenesis and neurogenesis

[283]

CD-1 mice

VEGF protein

Promotion of angiogenesis

[284]

MCAO Rats

Brain tissue

Amplification of angiogenesis and vascular stabilization

[285, 286]

MMP-9

MCAO Mice

Brain tissue

Promotion of angiogenesis and glial scar degradation

[184]

PDGF

human umbilical vein endothelial cells / Fertilized chicken embryos

endothelial cells

Augmentation of angiogenesis

[190]

PDGF-D

MCAO Mice

Brain tissue

Contribution to neovascularization by rescuing pericyte functions

[189]

PDGF-BB

Stroke Patients

plasma

Plasma biomarker analysis

[191]

PTX3

acute cerebral infarction Patients

plasma

Biomarker analysis

[287]

MCAO Mice

Brain tissue

Promotion of angiogenesis and neuronal survival

[187]

IL-6

Cerebrovascular injury Model

Brain tissue

Repair of damaged brain vasculature

[194]

MCAO mice

Brain tissue

Angiogenesis and functional recovery

[288]

IL-8

MCAO rats

Brain tissue

Increase in VEGF production and angiogenesis

[192]

TGF-β

MCAO Mice

oxygen − glucose deprivation model

Promotion of angiogenesis and repression of apoptosis

[185]

caveolin-1

MCAO Mice

Brain tissue

Neovascularization and astrogliosis

[186]

patients with Moyamoya disease

plasma

Biomarker analysis

[289]

MiRNA-26a

MCAO Rats

Brain tissue

Promotion of angiogenesis

[200, 201]

miR‑210

MCAO Mice

Brain tissue

Promotion of angiogenesis

[202]

lncRNA HOTAIR

OGD hBMVECs cell/neonatal patients with HIE

Plasma / cell

Promotion of angiogenesis

[203]