Table 2 Cargos associated with tumor growth, metabolism, invasion, and metastasis, along with their roles in stroke
Biomarker | Function in glioma | Patients / Models | Samples / treatment | Proposed Action in Stroke | Ref. |
|---|---|---|---|---|---|
L1CAM | Glioblastoma cell motility, proliferation, and invasiveness | Stroke Patients | Plasma | Biomarker Analysis | [139] |
TrkB | Promotion of glioblastoma aggressiveness | MCAO Mice / Stroke Patients | Primary astrocytes / Brain tissue | Promotion of Brain Injury and edema formation | [140] |
| Â | Â | BDNF TrkB receptor inhibitor-treated stroke mice model | Brain Tissue | Enhancement of neuroplasticity and acceleration of motor recovery | [144] |
| Â | Â | Post-stroke depression mice model | Brain tissue | Reduction of post-stroke depression | [146] |
| Â | Â | MCAO Rats | Â | Enhancement of corticospinal synaptic connections | [145] |
AQP4 | Influence on tumor cell fate toward invasiveness or apoptosis | AQP4–/– mice | Brain tissue | Promotion of brain edema | [280] |
miR-148a | Promotion of glioblastoma proliferation and metastasis | Patients with acute ischemic stroke | Peripheral Blood Cells | Biomarker analysis | [152] |
| Â | Â | Patients with ischemic stroke | Blood sample | Biomarker analysis | [153] |
HIF-1α | Promotion of glioblastoma progression and radioresistance | MCAO Mice | Brain tissue | Time-based biomarker analysis | [162] |
| Â | Â | H2O2 or hypoxia treated cell | Cell lysates | Protection against oxidative stress | [165] |
| Â | Â | Infected Mice / OGD cells | brain tissue / Cells | Modulation of ferroptosis-induced brain injury and neuroinflammation | [164] |
miR-221 | Tumor progression and temozolomide resistance | Acute ischemic stroke patients / MCAO Mice | Plasma / Brain tissue | Modulation of proinflammatory response | [159] |
miR-151a | Inhibition of XRCC4-mediated DNA repair | Acute cerebral infarction Patients | Serum | Biomarker analysis | [160] |
miR-301a | Tumor proliferation and invasion | MCAO Mice | Brain Tissue | Promotion of cell apoptosis and inflammatory response | [281] |
MiR-375 | suppress glioma proliferation, migration, and invasion | Acute ischemic stroke patients | Serum | Expression profile analysis | [148] |
| Â | Â | Ischemia/reperfusion rats / hypoxia/reoxygenation PC12 cell | Brain tissue / MiR-375 mimic | Suppression of apoptosis and oxidative stress | [282] |