Fig. 3

Glioma-derived EVs and their role in stroke. Glioma-derived extracellular vesicles carry cargos that have been widely reported in stroke and play coherent roles in both conditions. Abbreviations: IL-6 = interleukin-6, SDF-1α = stromal cell-derived factor 1 alpha, IFN-γ = interferon gamma, PD-L1 = programmed cell death ligand-1, L1CAM = neural cell adhesion molecule L1, TrkB = tropomyosin receptor kinase B, AQP4 = aquaporin 4, HIF-1α = hypoxia-inducible factor 1 alpha, VEGF = vascular endothelial growth factor, PDGF = platelet-derived growth factor, MMPs = matrix metalloproteinases, CXCR4 = C-X-C chemokine receptor type 4