Do microglia metabolize fructose in Alzheimer’s disease?

Table 1 RNA sequencing provides evidence for fructose metabolism in microglia^a

Human				Mouse
Gene	Protein	Expressed	Specific	Gene	Protein	Expressed	Specific
AKR1B1	Aldose reductase	Yes	Yes	Akr1b3	Aldose reductase	Yes	Yes
AKR1B10	Small intestine reductase/ AR-like protein 1	Yes	No	Akr1b8	Aldose reductase	Yes	No
ALDOA	Aldolase A	Yes	Yes	Aldoa	Aldolase A	Yes	No
ALDOB	Aldolase B	Yes	No	Aldob	Aldolase B	Yes	No
ALDOC	Aldolase C	Yes	No	Aldoc	Aldolase C	Yes	No
HK1	Hexokinase 1	Yes	No	Hk1	Hexokinase 1	Yes	No
HK2	Hexokinase 2	Yes	Yes	Hk2	Hexokinase 2	Yes	Yes
HK3	Hexokinase 3	Yes	No	Hk3	Hexokinase 3	Yes	Yes
GCK	Glucokinase	Yes	No	Gck	Glucokinase	Yes	No
KHK*	Ketohexokinase	Yes	No	Khk*	Ketohexokinase	Yes	Yes
SLC2A1	Glucose transporter 1	Yes	No	Slc2a1	Glucose transporter 1	Yes	No
SLC2A5	Glucose transporter 5	Yes	Yes	Slc2a5	Glucose transporter 5	Yes	Yes
SORD	Sorbitol dehydrogenase	Yes	No	Sord	Sorbitol dehydrogenase	Yes	Yes

ISSN: 1742-2094