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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Fig. 7

ACY-1215 reversed SNI-elevated production of chemokine CCL7 and CXCL13. (A) The experimental timeline for multiplex cytokine and chemokine analysis. (B) Heat map data from multi-factor sequencing analysis of spinal cord tissues from sham + DMSO (Sham), SNI + DMSO (SNI), and SNI + ACY-1215 group mice. Expression levels of IL-1β (C), IL-6 (D), TNF-α (E), CCL7 (F), and CXCL13 (G) were upregulated in the SNI group compared to the sham group and downregulated in the SNI + ACY-1215 group compared to the SNI group. Data are presented as means ± SEM; n = 6. Sham vs. SNI *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; SNI vs. SNI + ACY-1215#p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001

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Journal of Neuroinflammation

ISSN: 1742-2094