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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Fig. 5

Neuropathic pain enhanced HDAC6-STAT3 interaction, which was decreased by ACY-1215. (A) L4-L6 spinal cord tissues were collected from sham or SNI mice treated with or without ACY-1215. Tissue lysates (input) were immunoprecipitated with anti-STAT3 and immunoblotted for HDAC6, Ac-STAT3, and STAT3. (B) Representative western blots of target proteins. (C-E) Protein levels of HDAC6 (C), STAT3 (D), and Ac-STAT3 (E) in the spinal cord. The values were quantified relative to tubulin and normalized as fold change compared to the sham group receiving vehicle. Data are presented as means ± SEM; n = 4, Sham vs. SNI *p < 0.05, SNI vs. SNI + ACY-1215 #p < 0.05; one-way ANOVA followed by Tukey’s post hoc tests

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Journal of Neuroinflammation

ISSN: 1742-2094