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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Fig. 3

HDAC6 and p-STAT3 primarily co-localize with NeuN and, to a lesser extent, with GFAP and Iba1 in the L4-L6 dorsal horn of SNI mice. (A-B) Representative confocal images showing the co-localization of HDAC6 (red, A) or p-STAT3 (red, B) with NeuN, GFAP, and Iba1 (green) in the spinal dorsal horn of SNI-operated mice. (C-D) Percentages of HDAC6-positive/negative cells (C) and STAT3-positive/negative cells (D) in NeuN-, GFAP- and Iba1-positive cells in spinal dorsal horn. (E-F) Representative images showing the co-localization of HDAC6 (red, E) or p-STAT3 (red, F) with CGRP (green), and IB4 (blue) in L4-L6 spinal dorsal horn of Sham and SNI-operated mice. Scale bar = 100 μm, n = 5

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Journal of Neuroinflammation

ISSN: 1742-2094