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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Fig. 10

Schematic summary of HDAC6/STAT3 signaling in neuropathic pain. Left: SNI increases the interaction between HDAC6 and STAT3. HDAC6 regulates STAT3 phosphorylation/acetylation balance and promotes phosphorylation. This enhances STAT3 activity, facilitating its nuclear translocation and subsequent transcription of pro-inflammatory mediators (CCL7, TNF-α, IL-1β) which contribute to neuropathic pain. Right: Treatment with the HDAC6 inhibitor ACY-1215 suppresses HDAC6-STAT3 interaction, increases STAT3 acetylation, and reduces STAT3 phosphorylation. This reduces STAT3 nuclear translocation and the production of CCL7, TNF-α, and IL-1β, thereby alleviating pain

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Journal of Neuroinflammation

ISSN: 1742-2094