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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Fig. 1

Histone deacetylase 6 (HDAC6) inhibitor ACY-1215 attenuated mechanical pain in SNI-operated mice. (A) The experimental timeline diagram shows the protocol for constructing the SNI mouse model and the administration of treatments. ACY-1215 (20 mg/kg/day) or vehicle (10% DMSO in saline) was administered starting from day 1 post-SNI and continued daily until day 13. Baseline (BL) thresholds were measured one day before any treatment, and mechanical pain thresholds were assessed every two days thereafter. (B) Mechanical thresholds for different groups of male mice in von Frey tests. Data are shown as individual values with means ± SEM; n = 8 mice per group. RM two-way ANOVA followed by Tukey’s post hoc tests. Sham vs. SNI **p < 0.01, ***p < 0.001; SNI vs. SNI + ACY-1215 ##p < 0.01, ###p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094