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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy

Fig. 9

The inhibition of NETs formation alleviated the disruption of TJs and AJs by activating Wnt3/β-catenin/TCF4 signaling pathway. A Expression levels of Wnt/β-catenin/TCF4 signaling proteins in the hippocampus were detected by Western blot (n = 6). B–H The quantification analysis of Wnt/β-catenin/TCF4 signaling proteins expression levels (n = 6). I Wnt3 is predominantly secreted by neurons in the hippocampal CA1 region of septic mice. J Quantification of the mean fluorescence intensity of Wnt3 in CA1 region (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; BBB: Blood–brain barrier; TJs: Tight junctions; AJs: adherens junction (ns: no significance, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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Journal of Neuroinflammation

ISSN: 1742-2094