Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy

Fig. 7

The inhibition of NETs improved the top 1 modules associated proteins expression in the hippocampus. A Double labeling IF staining of VCL with ECs (CD31) after GSK484 treatment in the hippocampus (n = 6). B Quantification of the fluorescence intensity of VCL in CD31-positive area (n = 6). C Quantification of the mean fluorescence intensity of VCL in all area (n = 6). D Double labeling IF staining of Fermt1 with ECs (CD31) after GSK484 treatment in the hippocampus (n = 6). E Quantification of the fluorescence intensity of Fermt1 in CD31-positive area (n = 6). F Quantification of the mean fluorescence intensity of Fermt1 in all area (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; IF: immunofluorescence. (*p < 0.05, ***p < 0.001, ****p < 0.0001; ###p < 0.001, ####p < 0.0001; *sham vs CLP, #CLP vs CLP + GSK484)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094