Fig. 4
From: Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia
anti-VCAM-CD39 reduces hypoxic-ischaemic injury in the brain (A) HIF-1α was significantly reduced after anti-VCAM-CD39 treatment and (B) Circulating vWF in plasma was found to be significantly reduced after anti-VCAM-CD39 treatment (Data is Mean ± SEM; Saline: n = 16, Treated: n = 14; ***p < 0.001; unpaired t-test). Complete blot visible in Supplementary Fig. 4. (C) Endothelial cells immunolocalised with CD31 reveals that endothelial expression of ICAM-1 in the perilesional zone (indicated by arrows) is downregulated following anti-VCAM-CD39 treatment; higher magnification images are provided for the region marked with yellow squares