Fig. 3

ExMt disrupted endothelial barrier. (A) Representative images of lung were captured after DiR-labeled exMt (red) injection via in vivo imaging system (IVIS) (n = 4/group, one-way ANOVA). (B) The endothelial permeability was assessed by measuring trans-endothelial leakage of FITC-dextran (10 kDa, n = 4/group, paired t test). (C) Statistical analysis of Evans blue extravasation test in mice lung (n = 4/group, paired t test). (D) Representative western blotting bands and densitometric quantifications of Occludin (n = 6/group, paired t test). (E) Representative immunofluorescence images of Occludin staining in lung tissue (scale bars:100 μm)