Fig. 5

PLCγ2-P522R variant alleviates neuroinflammation in the brain tissue of female APP/PS1 mice. A IL-12p70 (p = 0.049) and IL-6 (p = 0.003) levels are significantly lower in the temporo-occipital cortex (CTX), whereas IL-1β (p = 0.021) and IL-8 (p = 0.026) levels are significantly lower in the hippocampus (HC) of APP/PS1xPLCγ2-P522R (A+/P^ki/ki) mice than in those of APP/PS1 (A+/P^wt/wt) mice. In addition, the IL-1β, IL-8, and TNF-α levels tended to decrease in the CTX group, whereas the IL-6, TNF-α, and TGF-β2 levels tended to decrease in the HCs of the A+/P^ki/ki mice compared with those of the A+/P^wt/wt mice. CTX A+/P^wt/wt n = 4 and A+/P^ki/ki n = 4; HC A+/P^wt/wt n = 5 and HC A+/P^ki/ki n = 6. Unpaired samples t test. All the data are presented as the means ± SEMs. Each data point represents an individual mouse