Fig. 1

GDF15 levels are elevated in the brains of septic mice. (A) Enzyme-linked immunosorbent assay (ELISA) results of plasma GDF15 levels in septic mice following intraperitoneal injection of LPS (10 mg/kg) for the indicated times. (B) ELISA measurements of GDF15 levels in the CSF of septic mice. (C) Western blots showing GDF15 expression levels in the brain tissues of septic mice. n = 3 mice per group, and bars indicate the means ± SEM. **P < 0.01, ***P < 0.001, ****P < 0.0001