Fig. 5

Rescue of expression of synaptic proteins in MyD88^-/- mice. Cuprizone treatment reduced the expression of a number of genes in the “chemical synaptic transmission” gene set (see also Fig. 3). In MyD88^-/- animals, a substantial subset of these genes were not or only slightly altered upon cuprizone treatment. (a) Ratios of expression after and before cuprizone treatment in WT animals. (b) Ratio of expression between MyD88^-/ and WT animals treated with cuprizone. The color corresponds to the -log10 transformed FDR. Most prominently, the glutamate transporters SLC1A6 and SLC1A3 (EAAT4 and GLAST), proteins involved in synapse structure and maintenance (e.g. GRID2, CBLN1, SHISA6), and several glutamate receptor subunits (GRIN2C, GRM1, GRM4, GRIA1, GRIA4) are rescued