Fig. 6

IDO1 in the ACC modulates anxiety-like behaviors associated with chronic migraine. (A-C) Locomotor activity and time spent in the center in the OFT (n = 10–12). (D-G) The time spent in open and closed arms, and the number of entries into open arms in the EPM (n = 10–12). (H-J) Locomotor activity and time spent in the center in the OFT (n = 20–22). (K-N) The time spent in open and closed arms, and the number of entries into open arms in the EPM (n = 20–22). The data are shown as mean ± SEM, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001; Student’s t test in (C, F), Mann-Whitney U test in (B, E, G), one-way ANOVA in (I, J, L-N)