Fig. 1

Inhibition of IL-6 trans-signaling improves NDS and reduces infarct volume 24 h after stroke in young male mice. (A) Experimental strategy for 24 h studies. (B) percentage body weight loss. (C) percentage spleen body weight. (D) Neurological deficit scores (NDS). (E) Infarct volume quantification and representative image of infarct in the vehicle and sgp130 treated groups. Data presented as mean ± SEM. n = 8–10/gp. Data were analyzed using the Unpaired t-test with Welch’s correction. NDS analyzed by Mann Whitney test and presented as a Median with an interquartile range. *p < 0.05; **p < 0.01, ***p < 0.001