Fig. 5
Microarray-based transcriptomic analysis of TBEV infection in the CNS of mice with different levels of susceptibility to the infection. (A) Principal component analysis revealed a separation of infected and control samples, as well as a transcriptional difference between mouse strains. More than 80% of the variability in the data is explained by the infection (PC1) and ~ 5% is explained by genotype (PC2). (B) The top 50 genes driving the genotype difference along the PC2 axis. (C) Overrepresentation analysis of the top 100 genes driving PC2, genotype-based separation (multiple testing correction by FDR, Padj < 0.1). Genes enriched in each Gene Ontology term are listed. Abbreviations: BP – biological process, CC – cellular component, MF – molecular function