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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism

Fig. 8

Bulk RNAseq analysis of iluzanebart-treated (ILU) mouse hippocampal tissue reveals differentially expressed genes. A Volcano plots of differentially expressed genes in hippocampus harvested from iluzanebart-treated (10, 30, 100, and 200 mg/kg) hTREM2 knock-in mice vs. IgG control-treated, n = 4–6 mice per group. B STRING analysis of genes of interest revealed gene clusters related to proliferation/ DNA replication, innate immune response, endoplasmic reticulum and protein folding, and AP-1/ transcription activation. C Gene ontology terms found to be associated with the differentially expressed genes (p < 0.05) are listed, ranked by adjusted p-value

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Journal of Neuroinflammation

ISSN: 1742-2094