Fig.7
From: Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis
B022 alleviated clinical symptoms, reduced serum antibody levels, and improved the morphological changes and complement deposition at NMJ in EAMG rats. A Flow chart of animal experiment. B HC and EAMG rat model picture. C Electrophysiology of healthy and EAMG rats. D The clinical scores of EAMG and B022 treated rats were recorded every day after treatment (n = 5). E The weights of EAMG and B022 treated rats on the last day (n = 5). F–I Serum AChR97-116 IgG, IgG1, IgG2a and IgG2b levels from these two groups were detected by ELISA (n = 5). J The morphological changes of spleen, lymph nodes and muscle were observed after B022 treatment. Arrow represents central artery; Five-pointed star represents splenic nodules; Diamond represents marginal area; Triangle represents red marrow; Square represents cortex; Circle represents medulla; Yellow circle represents lymph nodules. K Immunofluorescence of neuromuscular junction structure AChR clusters (green) and complement deposition C5b-9 (red). Data are displayed as means ± SD. Statistical analysis was conducted by independent sample t-test (*P < 0.05, **P < 0.01, ***P < 0.001, ns: non-significant)