A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats

Table 1 Effects of hyperamonemia and of treatment with anti-IL-17 on cytokines levels in plasma at 4 days of hyperamonemia

Cytokine	Hyperammonemic rats (% of control rats)
	Basal	Anti-IL-17
TNFα #	255 ± 53**	135 ± 27^a
IL-17	149 ± 13*	96 ± 15^a
IL-18	157 ± 24**	69 ± 14^aaa
IL-22	133 ± 7**	72 ± 8^aaaa
CCL2	149 ± 12*	79 ± 22^aa
CCL5	140 ± 14*	85 ± 8^aa
TGFβ	72 ± 11	120 ± 20^a
IL-4	88 ± 7	120 ± 13^*a
IL-10	103 ± 11	153 ± 19^**a
IL-6	97 ± 10	73 ± 7^*a
CX3CL1	102 ± 8	107 ± 19
CCL20	112 ± 18	105 ± 31
IL-15	106 ± 14	97 ± 24

TNF-α was analysed in plasma using an ELISA kit. The remaining cytokines were analysed by Western blot and the data are expressed as percentage of control rats. Values are the mean ± SEM of 7 rats per group. Values significantly different from control rats are indicated by asterisk (*p < 0.05, **p < 0.01) and from hyperammonemic rats by ‘a’ (a = p < 0.05, aa = p < 0.01, aaa = p < 0.001, aaaa = p < 0.0001)

ISSN: 1742-2094