Fig. 8
From: CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder
The detrimental effects of CD22 blockade on NMOSD pathology involve SYK-GSK3β signaling. A Flow chart depicting the experimental procedures. The mice received R406 starting from the onset of modeling until they were sacrificed. B, C Assessment of the phosphorylation levels of SYK and GSK3β in the indicated groups of NMOSD mice; n = 4 per group. D T2WI scans showing brain lesions in the indicated groups of NMOSD mice. Bar graph showing lesion volume in the indicated groups of NMOSD mice. Red lines mark the lesion areas; n = 6 per group. The data are presented as the mean ± SEM. *p < 0.05