Fig. 1

Affinity profiles of anti-αSyn (A), -Aβ (D) and -tau (G) IgG nAbs. Data are presented as two-site inhibition curves of random pooled age- and sex-matched plasma samples (n = 10) from normal controls (black triangles and line), AD (green dots and line), PD (blue triangles and line) and DLB (red squares and line). Binding affinities of individual samples of nAbs to αSyn were analyzed in the presence of (B) 0.2 nM and (C) 2 nM, to Aβ in the presence of (E) 0.06 nM and (F) 0.6 nM, and to tau in the presence of (H) 0.1 nM and (I) 1 nM. Data are presented as “% of max binding” in truncated violin plots with median (horizontal line). Group comparisons were performed by applying multiple linear regression models including covariates age and sex and post hoc multiple comparison testing using Tukey’s range test. Statistically significant p-values (< 0.5) are depicted