Fig. 4

Glyphosate exposure followed by a recovery period increases phosphorylated pathological tau. (A-D) Soluble and insoluble fractions of phosphorylated tau at Threonine (Thr) 181 and Serine (Ser) 396 in hippocampal (Hp) and cortex (Ctx) tissue. (E, F) AT8 (Ser 202/Thr 205) + cell number was significantly elevated in the CA1 region of the Hp of 3xTg-AD 50 mg/kg and 500 mg/kg. Abbreviations: DS = dorsal subiculum, DG = dentate gyrus, CA1 = cornus ammonis 1. Bar graphs are means ± SE. For box plots, the center line represents the median value, the limits represent the 25th and 75th percentile, and the whiskers represent the minimum and maximum value of the distribution. Bar graphs are means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001