Fig. 1
Serum PRL levels were associated with MCI and decreased hippocampal volumes in T2DM patients. (A) Associations between levels of pituitary hormones and risk of MCI were adjusted for age, education, sex, smoking, SBP, FBG, FINS, FCP, HbA1c, HOMA-IR. (B) Relative weight analysis of pituitary hormones in MCI prediction model. (C) Associations between quartiles of serum PRL levels and the prevalence of MCI. (D) Odds ratio (OR) of MCI according to quartiles of serum PRL levels were adjusted for age, education, sex, SBP, DBP, TC, HDL-C, LDL-C, FBG, HOMA-IR. Q4 is the reference group. (E) Associations between serum PRL levels and multiple cognitive subdomains. Model 1 was unadjusted. Model 2 was adjusted for age. Model 3 was adjusted for age, education and sex. (F) Associations between quartiles of serum PRL levels and the volumes of hippocampus after controlling for age, education, sex and TIV. (G) An example of Freesurfer v.7.2 hippocampal segmentation with coronal. (H) Comparisons about the volumes of hippocampal subregions (CA1, CA3, CA4, GC-DG and subiculum) between quartiles of serum PRL levels. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001; ns, not significant; one-way ANOVA (F, H)