Fig. 2
From: Metabolic-driven analytics of traumatic brain injury and neuroprotection by ethyl pyruvate
Profound changes in metabolism following TBI. A PCA with 95% confidence ellipses demonstrating a clear separation between the sham-Veh and CCI-Veh groups. B Pie chart showing the percentage of altered metabolites in each metabolic super family. Amino Acids composed the largest portion of the significantly altered metabolites with 43% of the amino acid metabolites significantly changing. C Volcano plot of the metabolites showing a twofold change in concentration following injury (p < 0.05). Numbered points indicate key metabolites identified in the Random Forest and pathway analysis associated with injury induced changes in metabolism (see Fig. 8). 1. cysteine; 2. glutathione disulfide; 3. GABA; 4. acetyl CoA; 5. homocarnosine; 6. alpha-ketoglutarate; 7. 4-acetoamidobutanoate; 8. glucose; 9. hypotaurine; 10. putrescine; 11. cystathionine; 12. opthalmate; 13. agmantine