Fig. 10
From: Metabolic-driven analytics of traumatic brain injury and neuroprotection by ethyl pyruvate
Significantly altered metabolites associated with energy metabolism following EP treatment in the injured brain. Significantly altered pathways following EP treatment included pyruvate metabolism, the TCA cycle, and glycolysis/gluconeogenesis. Phosphoenolpyruvate was a metabolic hit in all three pathways, and 2-phosphoglycerate was a metabolic hit in glycolysis/gluconeogenesis. Between group comparisons of the mean (± standard deviation) metabolite concentrations (Log10), using one way analysis of variance where *p < 0.05, ***p < 0.001