Fig. 6

Hypothesis for effectiveness of ABT-263 in EAE. Initial inflammatory insult and injury induces microglia to undergo reactivity and gliosis and may induce senescence in a subset of microglia (2). Senescent microglia may secrete more proinflammatory factors like TNFα, exacerbating local inflammatory activity (3a, top). Treatment with ABT-263 may induce apoptosis in the subset of senescent, proinflammatory microglia and macrophages, reducing the secretion of inflammatory factors into the local milieu, and therefore limiting further inflammatory activity (3b, bottom)