Table 3 Complement proteins and complement regulatory proteins stratified according to CFH rs1061170 genotype

 C3 [µg/ml]

876 (398)

800 (243)

0.58

 C3a [ng/ml]

573 (251)

435 (111)

0.0072

 C5a [ng/ml]

27.09 (11.07)

26.10 (14.65)

0.60

 C3a/C3-ratio [%]

0.074 (0.037)

0.058 (0.018)

0.011

Complement regulatory proteins, mean (SD)

 CD35 + CD4 + T cells [%]

4.47 (1.83)

3.60 (1.05)

0.071

 CD35 + CD8 + T cells [%]

6.75 (2.98)

4.96 (3.58)

0.024

 CD35 + Monocytes [%]

24.26 (3.82)

25.60 (4.15)

0.27

 CD35 + Classical monocytes [%]

26.54 (4.47)

29.41 (5.32)

0.077

 CD35 + Intermediate monocytes [%]

22.01 (9.04)

19.16 (6.78)

0.28

 CD35 + Non-classical monocytes [%]

9.74 (8.26)

6.67 (4.28)

0.27

 CD46 + CD4 + T cells [%]

96.94 (2.00)

97.19 (1.72)

0.61

 CD46 + CD8 + T cells [%]

98.82 (2.30)

98.43 (2.68)

0.60

 CD46 + Monocytes [%]

99.12 (0.96)

99.01 (0.53)

0.52

 CD46 + Classical monocytes [%]

99.76 (0.26)

99.54 (0.38)

0.043

 CD46 + Intermediate monocytes [%]

99.87 (0.26)

99.49 (0.70)

0.050

 CD46 + Non-classical monocytes [%]

92.21 (9.03)

94.76 (3.20)

0.043

 CD59 + CD4 + T cells [%]

92.70 (5.34)

91.99 (7.15)

0.68

 CD59 + CD8 + T cells [%]

67.05 (8.76)

71.10 (10.27)

0.16

 CD59 + Monocytes [%]

48.09 (5.29)

48.77 (1.85)

0.27

 CD59 + Classical monocytes [%]

51.12 (2.53)

51.43 (2.12)

0.59

 CD59 + Intermediate monocytes [%]

26.95 (17.91)

26.19 (16.65)

0.98

 CD59 + Non-classical monocytes [%]

45.92 (14.43)

48.46 (14.47)

0.28

 CD11b + Monocytes [%]

98.04 (0.68)

97.81 (0.94)

0.36

 CD11b + Classical monocytes [%]

97.63 (0.84)

97.31 (1.26)

0.33

 CD11b + Intermediate monocytes [%]

99.69 (0.48)

99.84 (0.25)

0.065

 CD11b + Non-classical monocytes [%]

99.83 (0.24)

99.88 (0.14)

0.19