Fig. 6

PLX5622 alleviates anxiety and repetitive behavioral deficits in VPA-model mice. A, B Open field test. Time spent in center and periphery zone (A) and total distance (B) during test for three groups of mice: saline, VPA and VPA + PLX5622. Two-way ANOVA for (A) and one-way ANOVA for (B); n = 8–12 per group. C–E, Repetitive behavior was evaluated by the time spent in self-grooming (C), and number of buried marbles in marble burying test (D, E). One-way ANOVA for (C) and E n = 8–11 per group. ***p < 0.001; **p < 0.01; *p < 0.05; “ns” denotes no statistical significance. Data are expressed as mean ± SEM