Fig. 1

PLX5622 rescues social behavioral deficits in the Cntnap2 KO mice. A Experimental timeline. After weaning on P21, 3–5 Cntnap2 WT and KO pups were sacrificed for histological test, while others were supplied with PLX5622 (1200 ppm) or normal chow (control) for 10 days, following which mice were returned to normal chow for the remainder of the study. One cohort of mice were killed at P31 or P65, and brain tissues were collected for histological test. Another cohort of mice underwent a battery of behavioral tasks at P70-P80. B, C Three-chamber social interaction test for four groups of Cntnap2 WT and KO mice treated or not treated with PLX5622 (as labeled in the inset of (C). Sniffing time with Stranger 1 and Object in phase 1 (B); sniffing time with Stranger 1 and Stranger 2 in phase 2 (C). n = 8–13 per group; two-way ANOVA for (B) and (C). D Reciprocal social interaction test for all groups. n = 6–8 per group; one-way ANOVA. ***p < 0.001; **p < 0.01; “ns” denotes no significance. Data are expressed as mean ± SEM